Hydroxypropyl Methylcellulose (HPMC) i polymer inoshanda zvakasiyana-siyana inoshandiswa zvakanyanya mumaindasitiri akasiyana siyana, kusanganisira mishonga, chikafu, zvizorwa, uye kuvaka.Hunhu hwayo hwakasiyana hunoita kuti ive yakanakisa mumiriri wezvikumbiro senge inodzorwa kuburitswa kwezvinodhaka, thickening agents, bhaisikopo coating, uye zvekuvakisa.Muchinyorwa chino, tichaongorora nzira yekumisa yeHPMC, tichiongorora kukosha kwayo, matekiniki, uye mashandisiro.Kunzwisisa nzira yekumisa yeHPMC kwakakosha pakugadzirisa mashandiro ayo uye kuwana mhedzisiro inodiwa mundima dzakasiyana.
Kukosha kwekuparara kweHPMC
Kunyungudika kweHPMC kunoreva maitiro ekuparadzira nekunyungudutsa iyo polima mune yemvura svikiro.Iyi nhanho yakakosha sezvo ichitarisa chiyero chekuburitsa, bioavailability, uye kuita kweHPMC-yakavakirwa zvigadzirwa.Maitiro ekumisa eHPMC anoenderana nezvinhu zvakasiyana, kusanganisira giredhi reHPMC, particle size, tembiricha, pH, uye chimiro chepakati.Nekudzidza nzira yekumisa, vaongorori nevagadziri vanogona kuongorora kunyungudika, kuburitsa kinetics, uye kuita kwese kweHPMC maumbirwo, zvichitungamira mukusimudzirwa kwechigadzirwa uye optimization.
Matekiniki ekumisa HPMC
Matanho akati wandei anoshandiswa pakudzidza maitiro ekuparara kweHPMC.Nzira dzinonyanya kushandiswa dzinosanganisira:
a.Apparatus I (Basket apparatus): Iyi nzira inosanganisira kuisa muenzaniso weHPMC mudengu remesh, rinobva ranyudzwa musvikiro rekunyunguduka richimutswa.Iyi tekinoroji inowanzo shandiswa pakukurumidza-kuburitswa maumbirwo uye inopa ruzivo rwakakosha nezveyero yekuparara uye kuburitsa chimiro cheHPMC.
b.Apparatus II (Paddle apparatus): Muiyi nzira, sampu inoiswa mumudziyo wekunyungudika, uye chikwambo chinoshandiswa kushungurudza pakati.Iyi tekinoroji yakakodzera kune ese ari maviri-ichimbi-chimbi-kuburitswa uye akawedzera-kuburitswa maumbirwo, achipa manzwisisiro muyero yekuparara uye kuburitsa kinetics yeHPMC.
c.Apparatus III (Reciprocating cylinder apparatus): Iyi nzira inosanganisira kuisa sample muhumburumbira rinodzokororwa, rinofamba richidzokera kumashure musvikiro rekunyungudutswa.Iyi nzira inowanzo shandiswa pakudzidza HPMC-yakavakirwa yakawedzera-kuburitswa maumbirwo uye inopa ruzivo nezvehuwandu hwekuburitswa uye maitiro ekuparadzira zvinodhaka.
d.Apparatus IV (Flow-through cell apparatus): Nzira iyi inonyanya kushandiswa pakudzidza HPMC-based transdermal patches kana membranes.Sample inoiswa pakati pemakamuri maviri, uye iyo disolution medium inotenderwa kuyerera kuburikidza nemuenzaniso, kutevedzera kuburitswa kwezvinodhaka kuyambuka membrane.
Zvishandiso zveHPMC dissolution nzira
Iyo yekumisa nzira yeHPMC inowana yakakura mashandisirwo mumaindasitiri akasiyana:
a.Indasitiri yemishonga: HPMC inoshandiswa zvakanyanya sematrix polymer kune inodzorwa kuburitswa kwemishonga.Iyo nzira yekumisa inobatsira kuona chiyero chekuburitsa, hunhu hwekuparadzira zvinodhaka, uye nzira yekuburitsa yeHPMC-yakavakirwa mahwendefa, makapisi, uye pellets.Ruzivo urwu rwakakosha pakugadzirisa kuendeswa kwezvinodhaka uye kuve nechokwadi chekuenderana uye fungidziro yekurapa kwemhedzisiro.
b.Indasitiri yechikafu: HPMC inoshandiswa seyakakora uye inodzikamisa mumiriri muzvigadzirwa zvekudya zvakaita sesosi, madhirezi, uye zvinwiwa.Iyo nzira yekunyungudutsa inobatsira mukunzwisisa iyo hydration uye solubility maitiro eHPMC mune akasiyana echikafu matrices, achibatsira mukuvandudza mameseji, kugadzikana, uye hunhu hwekunzwa hwekupedzisira zvigadzirwa.
c.Indasitiri yezvizora: HPMC inoshandiswa muzvizora uye zvigadzirwa zvekuchengeta munhu semugadziri wemufirimu, emulsion stabilizer, uye viscosity modifier.Iyo nzira yekunyungudutsa inobatsira kuongorora kunyungudika uye firimu-kugadzira zvimiro zveHPMC, kuve nechokwadi cheinodiwa chigadzirwa magadzirirwo, kupararira, uye pasherufu-hupenyu kugadzikana.
